Literature summary for 3.4.21.107 extracted from

Tennstaedt, A.; Poepsel, S.; Truebestein, L.; Hauske, P.; Brockmann, A.; Schmidt, N.; Irle, I.; Sacca, B.; Niemeyer, C.M.; Brandt, R.; Ksiezak-Reding, H.; Tirniceriu, A.L.; Egensperger, R.; Baldi, A.; Dehmelt, L.; Kaiser, M.; Huber, R.; Clausen, T.; Ehrmann, M.
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates (2012), J. Biol. Chem., 287, 20931-20941.

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Application

Application	Comment	Organism
medicine	human isoform HTRA1 degrades aggregated and fibrillar tau, a protein that is critically involved in various neurological disorders. Neuronal cells and patient brains accumulate less tau, neurofibrillary tangles, and neuritic plaques, respectively, when HTRA1 is expressed at elevated levels. HTRA1 mRNA and HTRA1 activity are up-regulated in response to elevated tau concentrations	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92743	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
tau protein + H2O	enzyme degrades aggregated and fibrillar tau, a protein critically involved in various neurological disorders	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
HtrA1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	isoform HTRA1 mRNA and HTRA1 activity are up-regulated in response to elevated tau concentrations	up

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Release 2023.1 (January 2023)