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Literature summary for 3.4.21.107 extracted from

  • Hoy, B.; Geppert, T.; Boehm, M.; Reisen, F.; Plattner, P.; Gadermaier, G.; Sewald, N.; Ferreira, F.; Briza, P.; Schneider, G.; Backert, S.; Wessler, S.
    Distinct roles of secreted HtrA proteases from gram-negative pathogens in cleaving the junctional protein and tumor suppressor E-cadherin (2012), J. Biol. Chem., 287, 10115-10120.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.107

Protein Variants

Protein Variants Comment Organism
S225A inactive mutant Campylobacter jejuni
S236A inactive mutant Shigella flexneri
S236A inactive mutant Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-associated Shigella flexneri 16020
-
membrane membrane-associated Campylobacter jejuni 16020
-
membrane membrane-associated Escherichia coli 16020
-

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni
-
-
-
Escherichia coli B7UIK8
-
-
Escherichia coli E2348/69 B7UIK8
-
-
Shigella flexneri
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
 Campylobacter jejuni ?
-
 ?
E-cadherin + H2O enzyme cleaves E-cadherin on host cells Shigella flexneri ?
-
 ?
E-cadherin + H2O enzyme cleaves E-cadherin on host cells Campylobacter jejuni ?
-
 ?
E-cadherin + H2O enzyme cleaves E-cadherin on host cells Escherichia coli ?
-
 ?
E-cadherin + H2O enzyme cleaves E-cadherin on host cells Escherichia coli E2348/69 ?
-
 ?

General Information

General Information Comment Organism
physiological function HtrA deletion leads to severe defects in E-cadherin cleavage, loss of cell adherence, paracellular transmigration, and basolateral invasion. A conserved pocket in the active center exhibits pronounced proteolytic activity Campylobacter jejuni