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Literature summary for 3.4.21.107 extracted from

  • Bakker, D.; Buckley, A.M.; de Jong, A.; van Winden, V.J.; Verhoeks, J.P.; Kuipers, O.P.; Douce, G.R.; Kuijper, E.J.; Smits, W.K.; Corver, J.
    The HtrA-like protease CD3284 modulates virulence of Clostridium difficile (2014), Infect. Immun., 82, 4222-4232.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Clostridioides difficile Q180C8
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Clostridioides difficile 630 Q180C8
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Synonyms

Synonyms Comment Organism
CD630_32840
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 Clostridioides difficile

General Information

General Information Comment Organism
physiological function HtrA deletion mutant shows enhanced virulence in the Golden Syrian hamster model of acute Clostridium difficile infection. Deletion of HtrA shows a pleiotropic effect on the transcriptome of Clostridium difficile, including upregulation of the toxin A gene. The mutant shows reduced spore formation and adherence to colonic cells Clostridioides difficile