Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S328A | enzymatically inactive | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
extracellular | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
x * 70000, about 70000 kDa, GST-tagged enzyme, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
tuberous sclerosis complex 2 protein + H2O | Homo sapiens | specific substrate for HtrA1 which is cleaved both in vitro and in vivo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
glutathione-Sepharose bead chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-2780 cell | - |
Homo sapiens | - |
SKOV-3 cell | - |
Homo sapiens | - |
TOV-21G cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | HtrA1 shows no activity towards tuberous sclerosis complex 1 protein and bovine serum albumin | Homo sapiens | ? | - |
? | |
tuberous sclerosis complex 2 protein + H2O | specific substrate for HtrA1 which is cleaved both in vitro and in vivo | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 70000, about 70000 kDa, GST-tagged enzyme, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
high-temperature requirement A1 protease | - |
Homo sapiens |
HtrA1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | one of the targets of HtrA1 activity during fetal development is the tuberous sclerosis complex 2-tuberous sclerosis complex 1 pathway | Homo sapiens |