Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.107 extracted from

  • Shiga, A.; Nozaki, H.; Yokoseki, A.; Nihonmatsu, M.; Kawata, H.; Kato, T.; Koyama, A.; Arima, K.; Ikeda, M.; Katada, S.; Toyoshima, Y.; Takahashi, H.; Tanaka, A.; Nakano, I.; Ikeuchi, T.; Nishizawa, M.; Onodera, O.
    Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-beta1 via cleavage of proTGF-beta1 (2011), Hum. Mol. Genet., 20, 1800-1810.
    View publication on PubMed
Search for more literature for 3.4.21.107

Protein Variants

Protein Variants Comment Organism
additional information mutations in the HTRA1 gene cause a hereditary cerebral small-vessel disease, cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy Homo sapiens
S328A the mutation abolishes protease activity in HTRA1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information HTRA1 fails to cleave mature transforming growth factor-beta1 Homo sapiens ?
-
 ?
pro-transforming growth factor-beta1 + H2O
-
 Homo sapiens mature transforming growth factor-beta1 + latency-associated peptide latency-associated peptide is the N-terminal of pro-transforming growth factor-beta1 ?

Synonyms

Synonyms Comment Organism
high-temperature requirement A1 protease
-
 Homo sapiens
HtrA1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy-associated mutant HTRA1 decreases protease activity and fails to decrease transforming growth factor-beta family signaling Homo sapiens
physiological function HTRA1 decreases transforming growth factor-beta1 signaling triggered by pro-transforming growth factor-beta1 in the intracellular space Homo sapiens