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Literature summary for 3.4.21.107 extracted from

  • Chien, J.; He, X.; Shridhar, V.
    Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening (2009), J. Cell. Biochem., 107, 253-263.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.107

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AEBSF
-
 Homo sapiens
additional information not inhibited by benzyloxycarbonyl-VAD-fluoromethylketone Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule HtrA1 is localized to microtubules in both interphase and mitotic cells Homo sapiens 5874
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-tubulin + H2O Homo sapiens
-
 ?
-
 ?
beta-tubulin + H2O Homo sapiens
-
 ?
-
 ?
gamma-tubulin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
OV-202 cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-tubulin + H2O
-
 Homo sapiens ?
-
 ?
beta-tubulin + H2O
-
 Homo sapiens ?
-
 ?
gamma-tubulin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HtrA1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function HtrA1 is implicated in trophoblast cell migration and invasion, tumor progression, chemotherapy-induced cytotoxicity, osteoarthritis, age-related macular degeneration, and pathogenesis of Alzheimer's disease Homo sapiens