Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | Nma111p does not shuttle between the nucleus and cytoplasm | Saccharomyces cerevisiae | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Nma111p | contains an HtrA-like serine-protease domain | Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | lack of nuclear localisation of Nma111p causes late onset of cell death during chronological ageing | Saccharomyces cerevisiae |
physiological function | Nma111p functions as a nuclear serine protease that is necessary for apoptosis under cellular stress conditions, such as elevated temperature or treatment of cells with hydrogen peroxide to induce cell death. The nuclear localisation of Nma111p is required for its function in response to oxidative stress | Saccharomyces cerevisiae |