Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CPII | cleavage of aggrecan by HtrA1 is strongly enhanced by HtrA1 agonists such as CPII, a C-terminal hexapeptide derived from the C-propeptide of procollagen IIalpha1 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S328A | active site mutant | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | Homo sapiens | the HtrA1-specific cleavage site is VQTV3562357TWPD within the interglobular domain of aggrecan | aggrecan fragments | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
articular cartilage | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | the HtrA1-specific cleavage site is VQTV3562357TWPD within the interglobular domain of aggrecan | Homo sapiens | aggrecan fragments | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HtrA1 | - |
Homo sapiens |
PRSS11 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | HtrA1 levels are highly elevated (about 7.8fold) in osteoarthritic cartilage | up |
General Information | Comment | Organism |
---|---|---|
physiological function | HtrA1 is a critical protease involved in proteoglycan turnover and cartilage degradation during degenerative joint disease | Homo sapiens |