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Literature summary for 3.4.21.107 extracted from
- The role of human HtrA1 in arthritic disease (2006), J. Biol. Chem., 281, 6124-6129.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene htrA, expression of His-tagged HtrA1 lacking the N-terminal insulin-like growth factor-binding protein and serine protease inhibitor domain in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| HtrA1 inhibitor | - |
Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | activates | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibronectin + H2O | Homo sapiens | HtrA is involved in cartilage catabolism | fibronectin peptide fragments | - |
? | |
| additional information | Homo sapiens | HtrA1 plays a role in arthritic disease, within the context of arthritis pathology HtrA1 contributes to cartilage degradation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged HtrA1 lacking the N-terminal insulin-like growth factor-binding protein and serine protease inhibitor domain from Escherichia coli by affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | synovial, main source of secreted enzyme | Homo sapiens | - |
| synovial fluid | elevated synovial HtrA1 levels in fluids obtained from rheumatoid and osteoarthritis patients | Homo sapiens | - |
| synovium | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biglycan + H2O | - |
Homo sapiens | ? | - |
? | |
| decorin + H2O | a small leucine-rich proteoglycan | Homo sapiens | decorin peptide fragments | - |
? | |
| fibronectin + H2O | - |
Homo sapiens | fibronectin peptide fragments | - |
? | |
| fibronectin + H2O | HtrA is involved in cartilage catabolism | Homo sapiens | fibronectin peptide fragments | - |
? | |
| additional information | HtrA1 plays a role in arthritic disease, within the context of arthritis pathology HtrA1 contributes to cartilage degradation, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HtrA1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00021 | - |
pH 8.5, 37°C, recombinant enzyme | Homo sapiens | HtrA1 inhibitor |
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Release 2023.1 (January 2023)
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