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Literature summary for 3.4.21.107 extracted from
- Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control (2008), Angew. Chem. Int. Ed. Engl., 47, 1332-1334.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| DKVLVVWAGQQ | MalS-derived peptide sequence | Escherichia coli |  |
| DNRNGNVYDF | - |
Escherichia coli | |
| DNRNGNVYFF | thermodynamic binding affinities of the peptide | Escherichia coli | |
| DNRNGNVYGF | - |
Escherichia coli | |
| DNRNGNVYIF | - |
Escherichia coli | |
| DNRNGNVYKF | - |
Escherichia coli | |
| DNRNGNVYLF | thermodynamic binding affinities of the peptide | Escherichia coli | |
| DNRNGNVYQF | - |
Escherichia coli | |
| DNRNGNVYSF | - |
Escherichia coli | |
| DNRNGNVYWF | - |
Escherichia coli | |
| DNRNGNVYYF | - |
Escherichia coli | |
| IVALGLVYQF | OmpC-derived peptide sequence | Escherichia coli | |
| additional information | allosteric activation of DegP by stress signals during bacterial protein quality control, DegP activation is based on an interaction of the activating peptide with PDZ domains | Escherichia coli | |
| YTMKAAGLGK | PhoA-derived peptide sequence | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Escherichia coli | allosteric activation of DegP by stress signals during bacterial protein quality control, regulation mechanism, pathway scheme, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | allosteric activation of DegP by stress signals during bacterial protein quality control, regulation mechanism, pathway scheme, overview | Escherichia coli | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bacterial PQC factor | - |
Escherichia coli |
| DegP | - |
Escherichia coli |
| HtrA protease | - |
Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
activation assay at | Escherichia coli |
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Release 2023.1 (January 2023)
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