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Literature summary for 3.4.21.107 extracted from
- The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells (2005), Appl. Environ. Microbiol., 71, 3205-3212.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| puromycin | increases level of misfolded proteins, HtrA is required for growth under conditions in which misfolded proteins accumulate | Campylobacter jejuni |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | HtrA is important both for adherence to and invasion of human INT407 epithelial cells | Campylobacter jejuni |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli DH5alpha, BL20 and BL78 | Campylobacter jejuni |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | Escherichia coli HtrA mutant | Escherichia coli |
| additional information | mutant strain NCTC11168deltahtrA cat, main part of the HtrA gene replaced | Campylobacter jejuni |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | wild type and HtrA mutant are not sensitive to H2O2, cumene hydroperoxide and paraquat, moreover the wild type is not sensitive to oxygen while the mutant has a reduced oxygen tolerance | Campylobacter jejuni |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| periplasm | - |
Campylobacter jejuni | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Campylobacter jejuni | - |
strain NCTC11168 | - |
| Campylobacter jejuni NCTC 11168 | - |
strain NCTC11168 | - |
| Escherichia coli | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HtrA protease | - |
Escherichia coli |
| HtrA protease | - |
Campylobacter jejuni |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | 44 | the HtrA mutant forms colonies with the same frequency as the wild type at 37°C and 42°C, the ability of the mutant to form colonies at 44°C was greatly reduced as compared to the wild type | Campylobacter jejuni |
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