Application | Comment | Organism |
---|---|---|
biotechnology | htrA mutants show improved expression of envelope-associated proteins | Escherichia coli |
medicine | aroC aroD HtrA mutant shows promise as a typhoid vaccine in humans | Salmonella enterica subsp. enterica serovar Typhimurium |
medicine | htrA mutants can act as vaccines | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
- |
Yersinia enterocolitica |
Protein Variants | Comment | Organism |
---|---|---|
H105R | loss of protease activity, no change in secondary structure | Escherichia coli |
S210A | loss of protease activity, no change in secondary structure | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
inner membrane | periplasmic side of the inner membrane | Escherichia coli | - |
- |
periplasm | - |
Escherichia coli | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Yersinia enterocolitica | deletion mutant is unable to grow at an elevated temperature and to survive within macrophages after phagocytosis | ? | - |
? | |
additional information | Escherichia coli | involved in the degradation of misfolded proteins | ? | - |
? | |
additional information | Salmonella enterica subsp. enterica serovar Typhimurium | mutants are deficient in their ability to survive in mice or macrophages | ? | - |
? | |
Protein + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | - |
? | - |
? | |
Protein + H2O | Escherichia coli | - |
? | - |
? | |
Protein + H2O | Yersinia enterocolitica | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Yersinia enterocolitica | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Arc repressor + H2O | - |
Escherichia coli | ? | - |
? | |
beta-casein + H2O | - |
Escherichia coli | ? | - |
? | |
colicin A lysis protein precursor + H2O | - |
Escherichia coli | ? | - |
? | |
IciA protein + H2O | inhibitor of DNA replication initiation | Escherichia coli | ? | - |
? | |
lambda repressor + H2O | N-terminal domain | Escherichia coli | ? | - |
? | |
additional information | deletion mutant is unable to grow at an elevated temperature and to survive within macrophages after phagocytosis | Yersinia enterocolitica | ? | - |
? | |
additional information | involved in the degradation of misfolded proteins | Escherichia coli | ? | - |
? | |
additional information | mutants are deficient in their ability to survive in mice or macrophages | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
Protein + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
Protein + H2O | - |
Escherichia coli | ? | - |
? | |
Protein + H2O | - |
Yersinia enterocolitica | ? | - |
? | |
Protein + H2O | denatured proteins aggregate to form a distinct S fraction, one third of the isolated S fraction is converted to trichloroacetic acid-soluble products, enzyme has a preference for valine or isoleucine as the residue preceding the cleavage site | Escherichia coli | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
oligomer | largest complexes are dodecamers, probably formed by dimerization of trimers, gel filtration experiments | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
DegP | - |
Escherichia coli |
Do protease | - |
Escherichia coli |
HtrA | - |
Escherichia coli |
HtrA2 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
HtrA2 | - |
Yersinia enterocolitica |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
55 | - |
- |
Escherichia coli |