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Literature summary for 3.4.21.106 extracted from

  • Kazama, Y.; Hamamoto, T.; Foster, D.C.; Kisiel, W.
    Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation (1995), J. Biol. Chem., 270, 66-72.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
fusion protein with maltose-binding protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-amidinophenylmethylsulfonyl fluoride complete inhibition at 1 mM Homo sapiens
antithrombin III 76% inhibition at 0.003 mM, 1U/ml heparin enhances inhibition Homo sapiens
Aprotinin 90% inhibition at 0.008 mM Homo sapiens
additional information no inhibition by soybean trypsin inhibitor and tissue factor pathway inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ optimal concentration: 5 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Protein + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor X + H2O activates factor X in the presence of factor VII Homo sapiens ?
-
?
additional information enzyme does not cleave factor VII R152E mutant Homo sapiens ?
-
?
Protein + H2O
-
Homo sapiens ?
-
?
zymogen factor VII + H2O cleaves between Arg152 and Ile153 Homo sapiens factor VIIa
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
Homo sapiens