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Literature summary for 3.4.21.105 extracted from
- The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity (2009), J. Mol. Biol., 394, 815-825.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-1 cells as a myc-tagged fusion protein by transient transfection | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R111A | processing of RHBDL2 is totally abolished | Homo sapiens |
| W110A | when cells are transfected with W110A, RHBDL2 is processed | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | RHBDL2 is produced as a proenzyme. Processing is required for activity. A highly conserved Arg residue on loop 1 of RHBDL2 plays a critical role. RHBDL2 is processed by a sulfonamide-sensitive protease | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RHBDL2 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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