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Literature summary for 3.4.21.105 extracted from

  • Lemberg, M.K.; Freeman, M.
    Cutting proteins within lipid bilayers: rhomboid structure and mechanism (2007), Mol. Cell, 28, 930-940.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of Rhomboid-1 with growth factor Spitz in COS-7 cells Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane intramembrane enzyme with 6 transmembrane segments Drosophila melanogaster 16020
-
membrane intramembrane enzyme with 6 transmembrane segments Escherichia coli 16020
-
membrane intramembrane enzyme with 6 transmembrane segments Haemophilus influenzae 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
growth factor Spitz + H2O Drosophila melanogaster Rhomboid-1 ?
-
?
additional information Drosophila melanogaster regulation, overview ?
-
?
additional information Escherichia coli regulation, overview ?
-
?
additional information Haemophilus influenzae regulation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Escherichia coli
-
gene glpG
-
Haemophilus influenzae P44783 gene glpG
-

Reaction

Reaction Comment Organism Reaction ID
cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains rhomboid structure and catalytic mechanism, catalytic dyad id formed by S201 and H254, structure-function modeling Escherichia coli
cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains rhomboid structure and catalytic mechanism, catalytic dyad id formed by S201 and H254, structure-function modeling Haemophilus influenzae
cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains rhomboid structure and catalytic mechanism, structure-function modeling Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
growth factor Spitz + H2O Rhomboid-1 Drosophila melanogaster ?
-
?
additional information regulation, overview Drosophila melanogaster ?
-
?
additional information regulation, overview Escherichia coli ?
-
?
additional information regulation, overview Haemophilus influenzae ?
-
?
additional information structure-function relationship, substrate entry, overview Escherichia coli ?
-
?
additional information structure-function relationship, substrate entry, overview Haemophilus influenzae ?
-
?
additional information structure-function relationship, substrate entry, Rhomboid active-site topology, overview Drosophila melanogaster ?
-
?

Subunits

Subunits Comment Organism
More molecular structure, alternative conformations for the putative gating helix 5 of GlpG, GlpG forms a water-filled cavity on the extracellular side of GlpG, with the catalytic serine at its base, overview Escherichia coli
More molecular structure, alternative conformations for the putative gating helix 5 of GlpG, overview Haemophilus influenzae

Synonyms

Synonyms Comment Organism
GlpG
-
Escherichia coli
GlpG
-
Haemophilus influenzae
rhomboid-1
-
Drosophila melanogaster