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Literature summary for 3.4.21.105 extracted from
- Rhomboid cleaves Star to regulate the levels of secreted Spitz (2007), EMBO J., 26, 1211-1220.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum membrane | - |
Drosophila melanogaster | 5789 | - |
| endosome | membranes of the late endosome compartment | Drosophila melanogaster | 5768 | - |
| membrane | Rhomboid is an intramembrane protein | Drosophila melanogaster | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chaperone Star + H2O | Drosophila melanogaster | cleavage of Star within its transmembrane domain both in cell culture and in flies, the enzyme is involved in regulation of levels of Spitz, the major Drosophila EGF receptor ligand, mechanism for modulating the activity of Star, thereby influencing the levels of active Spitz ligand, intracellular trafficking of Spitz isimpaired by Rhomboid-dependent cleavage of Star, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chaperone Star + H2O | cleavage of Star within its transmembrane domain both in cell culture and in flies, the enzyme is involved in regulation of levels of Spitz, the major Drosophila EGF receptor ligand, mechanism for modulating the activity of Star, thereby influencing the levels of active Spitz ligand, intracellular trafficking of Spitz isimpaired by Rhomboid-dependent cleavage of Star, overview | Drosophila melanogaster | ? | - |
? | |
| chaperone Star + H2O | a type II transmembrane protein, cleavage in the transmembrane sequence 298IVYMoxDTTEIRHQQF311 | Drosophila melanogaster | ? | - |
? | |
| additional information | Rhomboid cleaves both type I and type II transmembrane proteins | Drosophila melanogaster | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Rhomboid | - |
Drosophila melanogaster |
| rhomboid-1 | - |
Drosophila melanogaster |
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