Application | Comment | Organism |
---|---|---|
medicine | TgROM5 is able to cleave MIC adhesins. It likely provides the key protease activity necessary for invasion. The enzyme TgROM5 offers a target for therapeutic intervention against invasion by the deadly pathogen Toxoplasma gondii | Toxoplasma gondii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | TgROM4 is localized to the cell surface | Toxoplasma gondii | 9986 | - |
cell surface | TgROM5 is localized to the cell surface, primarily at the posterior of the parasite | Toxoplasma gondii | 9986 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
MIC adhesin + H2O | Toxoplasma gondii | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? | |
MIC adhesin + H2O | Toxoplasma gondii TgROM2 | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? | |
MIC adhesin + H2O | Toxoplasma gondii TgROM1 | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? | |
MIC adhesin + H2O | Toxoplasma gondii TgROM3 | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? | |
MIC adhesin + H2O | Toxoplasma gondii TgROM5 | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? | |
MIC adhesin + H2O | Toxoplasma gondii TgROM4 | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Toxoplasma gondii | - |
TgROM1 | - |
Toxoplasma gondii | - |
TgROM2 | - |
Toxoplasma gondii | - |
TgROM3 | - |
Toxoplasma gondii | - |
TgROM4 | - |
Toxoplasma gondii | - |
TgROM5 | - |
Toxoplasma gondii TgROM1 | - |
TgROM1 | - |
Toxoplasma gondii TgROM2 | - |
TgROM2 | - |
Toxoplasma gondii TgROM3 | - |
TgROM3 | - |
Toxoplasma gondii TgROM4 | - |
TgROM4 | - |
Toxoplasma gondii TgROM5 | - |
TgROM5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | TgROM2 | Toxoplasma gondii | - |
oocyte | TgROM3 | Toxoplasma gondii | - |
tachyzoite | TgROM1 | Toxoplasma gondii | - |
tachyzoite | TgROM4 is localized to the cell surface | Toxoplasma gondii | - |
tachyzoite | TgROM5 is localized to the cell surface, primarily at the posterior of the parasite | Toxoplasma gondii | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
MIC adhesin + H2O | - |
Toxoplasma gondii | ? | - |
? | |
MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii | ? | - |
? | |
MIC adhesin + H2O | - |
Toxoplasma gondii TgROM2 | ? | - |
? | |
MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii TgROM2 | ? | - |
? | |
MIC adhesin + H2O | - |
Toxoplasma gondii TgROM1 | ? | - |
? | |
MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii TgROM1 | ? | - |
? | |
MIC adhesin + H2O | - |
Toxoplasma gondii TgROM3 | ? | - |
? | |
MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii TgROM3 | ? | - |
? | |
MIC adhesin + H2O | - |
Toxoplasma gondii TgROM5 | ? | - |
? | |
MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii TgROM5 | ? | - |
? | |
MIC adhesin + H2O | - |
Toxoplasma gondii TgROM4 | ? | - |
? | |
MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii TgROM4 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TgROM1 | - |
Toxoplasma gondii |
TgROM2 | - |
Toxoplasma gondii |
TgROM3 | - |
Toxoplasma gondii |
TgROM4 | - |
Toxoplasma gondii |
TgROM5 | - |
Toxoplasma gondii |