Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method in the presence of Ca2+ | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Protein + H2O | Rattus norvegicus | enzyme circulates as a complex with mannose-binding protein, minimal functional unit for complement activation is a ASP homodimer bound to two mannose-binding protein trimeric subunits, complex is formed more readily in the presence of Ca2+ | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q9JJS8 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | zymogen is cleaved into the catalytically active protease | Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile) | mechanism | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Protein + H2O | - |
Rattus norvegicus | ? | - |
? | |
Protein + H2O | enzyme circulates as a complex with mannose-binding protein, minimal functional unit for complement activation is a ASP homodimer bound to two mannose-binding protein trimeric subunits, complex is formed more readily in the presence of Ca2+ | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | crystallographic experiments | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
MASP-2 | - |
Rattus norvegicus |