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Literature summary for 3.4.21.10 extracted from

  • Liu, X.; Chen, Q.; Zhu, J.; Fan, Y.; Ding, L.; Zhao, J.; Han, G.; Tian, W.; Qi, J.; Zhou, Y.; Lv, J.
    Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H-benzo[d]imidazol-2-yl carbamate derivatives (2012), Bioorg. Med. Chem. Lett., 22, 3554-3559.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-(2,4-dichlorophenyl)-1,2-oxazole-3-carbaldehyde
-
Homo sapiens
DV-1006
-
Homo sapiens
KF950
-
Homo sapiens
methyl (6-[[4-(trifluoromethyl)phenyl]sulfamoyl]-1H-benzimidazol-2-yl)carbamate
-
Homo sapiens
methyl [6-(butylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-(hexylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-(phenylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-(propan-2-ylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(2,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(2,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(2,5-dimethylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(2-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(2-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(2-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(3,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(3,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(3,4-dimethoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(3-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(3-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(3-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(4-bromophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(4-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(4-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(4-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[(4-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[benzyl(methyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
methyl [6-[bis(3-methylbutyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
-
Homo sapiens
N-alpha-tosyl-L-lysyl-chloromethyl-ketone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Nalpha-benzoyl-L-arginine 4-nitroanilide + H2O
-
Homo sapiens Nalpha-benzoyl-L-arginine + 4-nitroaniline
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.063
-
pH 8.0, 22°C Homo sapiens methyl [6-[bis(3-methylbutyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
0.31
-
pH 8.0, 22°C Homo sapiens methyl [6-[(2-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
0.47
-
pH 8.0, 22°C Homo sapiens methyl [6-(propan-2-ylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
1.03
-
pH 8.0, 22°C Homo sapiens methyl [6-(phenylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
1.25
-
pH 8.0, 22°C Homo sapiens methyl [6-[benzyl(methyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
1.27
-
pH 8.0, 22°C Homo sapiens methyl [6-[(2,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
1.55
-
pH 8.0, 22°C Homo sapiens methyl [6-[(2,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
1.59
-
pH 8.0, 22°C Homo sapiens methyl [6-[(3,4-difluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
1.64
-
pH 8.0, 22°C Homo sapiens methyl [6-[(4-bromophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
1.7
-
pH 8.0, 22°C Homo sapiens 5-(2,4-dichlorophenyl)-1,2-oxazole-3-carbaldehyde
1.77
-
pH 8.0, 22°C Homo sapiens methyl [6-(butylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
1.8
-
pH 8.0, 22°C Homo sapiens methyl [6-(hexylsulfamoyl)-1H-benzimidazol-2-yl]carbamate
1.81
-
pH 8.0, 22°C Homo sapiens methyl [6-[(3-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
2.4
-
pH 8.0, 22°C Homo sapiens methyl [6-[(4-fluorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.18
-
pH 8.0, 22°C Homo sapiens methyl [6-[(4-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
3.29
-
pH 8.0, 22°C Homo sapiens methyl [6-[(4-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
4.02
-
pH 8.0, 22°C Homo sapiens methyl [6-[(3,4-dichlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
5.06
-
pH 8.0, 22°C Homo sapiens methyl [6-[(3-methylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
5.75
-
pH 8.0, 22°C Homo sapiens methyl [6-[(2-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
7.5
-
pH 8.0, 22°C Homo sapiens methyl [6-[(3-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
7.52
-
pH 8.0, 22°C Homo sapiens methyl [6-[(4-chlorophenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
8.42
-
pH 8.0, 22°C Homo sapiens methyl [6-[(2-methoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
8.86
-
pH 8.0, 22°C Homo sapiens methyl [6-[(2,5-dimethylphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate
10.7
-
pH 8.0, 22°C Homo sapiens methyl (6-[[4-(trifluoromethyl)phenyl]sulfamoyl]-1H-benzimidazol-2-yl)carbamate
11.5
-
pH 8.0, 22°C Homo sapiens methyl [6-[(3,4-dimethoxyphenyl)sulfamoyl]-1H-benzimidazol-2-yl]carbamate