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Literature summary for 3.4.21.10 extracted from

  • Ding, L.; Zhu, J.; Zheng, C.; Sheng, C.; Qi, J.; Liu, X.; Han, G.; Zhao, J.; Lv, J.; Zhou, Y.
    Synthesis and acrosin inhibitory activity of substituted 4-amino-N-(diaminomethylene) benzenesulfonamide derivatives (2011), Bioorg. Med. Chem. Lett., 21, 6674-6677.
    View publication on PubMed
Search for more literature for 3.4.21.10

Application

Application Comment Organism
medicine acrosin represents a potential target for the design and development of male contraceptive agents Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,4-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
 Homo sapiens
2,6-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
 Homo sapiens
2-(4-chlorophenoxy)-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]acetamide
-
 Homo sapiens
2-bromo-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
 Homo sapiens
2-chloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
 Homo sapiens
3,4-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
 Homo sapiens
3-chloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
 Homo sapiens
3-methylbutyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
 Homo sapiens
4-(chloromethyl)-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
-
 Homo sapiens
butyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
 Homo sapiens
DV-1006
-
 Homo sapiens
ethyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
 Homo sapiens
KF950
-
 Homo sapiens
methyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
 Homo sapiens
N-alpha-tosyl-L-lysyl-chloromethylketone
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2,4,6-trimethylbenzamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2,6-difluorobenzamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(2-methylphenoxy)acetamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(2-methylpiperidin-1-yl)acetamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(3-methylphenoxy)acetamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methoxyphenoxy)acetamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methylphenoxy)acetamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methylpiperidin-1-yl)acetamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-nitrophenoxy)acetamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(piperidin-1-yl)acetamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-phenoxyacetamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-3,5-dinitrobenzamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-3-(trifluoromethyl)benzamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-ethoxybenzamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-ethylbenzamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-fluorobenzamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-methoxybenzamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-methylbenzamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]butanamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]pentanamide
-
 Homo sapiens
N-[4-[(diaminomethylidene)sulfamoyl]phenyl]propanamide
-
 Homo sapiens
propan-2-yl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
 Homo sapiens
propyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
-
 Homo sapiens
suramin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
sperm
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000027
-
 pH and temperature not specified in the publication Homo sapiens KF950
0.00013
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-ethoxybenzamide
0.00021
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-ethylbenzamide
0.00158
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]pentanamide
0.00206
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-methylbenzamide
0.00221
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-methoxybenzamide
0.0023
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-phenoxyacetamide
0.00235
-
 pH and temperature not specified in the publication Homo sapiens propan-2-yl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
0.00245
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2,4,6-trimethylbenzamide
0.0025
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-3,5-dinitrobenzamide
0.00251
-
 pH and temperature not specified in the publication Homo sapiens 3-methylbutyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
0.00299
-
 pH and temperature not specified in the publication Homo sapiens ethyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
0.00331
-
 pH and temperature not specified in the publication Homo sapiens propyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
0.0038
-
 pH and temperature not specified in the publication Homo sapiens 3,4-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
0.00384
-
 pH and temperature not specified in the publication Homo sapiens 4-(chloromethyl)-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
0.0042
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-nitrophenoxy)acetamide
0.00498
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methylpiperidin-1-yl)acetamide
0.00563
-
 pH and temperature not specified in the publication Homo sapiens 2,4-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
0.00596
-
 pH and temperature not specified in the publication Homo sapiens 2,6-dichloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
0.0063
-
 pH and temperature not specified in the publication Homo sapiens 2-chloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
0.007
-
 pH and temperature not specified in the publication Homo sapiens 3-chloro-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
0.00705
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-3-(trifluoromethyl)benzamide
0.00711
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-4-fluorobenzamide
0.00718
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2,6-difluorobenzamide
0.00741
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(piperidin-1-yl)acetamide
0.00763
-
 pH and temperature not specified in the publication Homo sapiens 2-bromo-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]benzamide
0.00892
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(3-methylphenoxy)acetamide
0.00898
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methylphenoxy)acetamide
0.009
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]propanamide
0.0093
-
 pH and temperature not specified in the publication Homo sapiens methyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
0.0093
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(2-methylphenoxy)acetamide
0.00935
-
 pH and temperature not specified in the publication Homo sapiens 2-(4-chlorophenoxy)-N-[4-[(diaminomethylidene)sulfamoyl]phenyl]acetamide
0.0095
-
 pH and temperature not specified in the publication Homo sapiens butyl 1-[2-([4-[(diaminomethylidene)sulfamoyl]phenyl]amino)-2-oxoethyl]piperidine-4-carboxylate
0.00958
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]butanamide
0.00984
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(4-methoxyphenoxy)acetamide
0.0099
-
 pH and temperature not specified in the publication Homo sapiens N-[4-[(diaminomethylidene)sulfamoyl]phenyl]-2-(2-methylpiperidin-1-yl)acetamide
0.1426
-
 pH and temperature not specified in the publication Homo sapiens N-alpha-tosyl-L-lysyl-chloromethylketone