Application | Comment | Organism |
---|---|---|
drug development | G-quadruplex-scaffold-based receptors are effective inhibitors of ChT by protein-surface recognition. This may provide a general strategy to generate synthetic combinatorial libraries of receptors to target different classes of proteins | synthetic construct |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | efficient binding and inhibition of ChT by a self-assembled DNA quadruplex with protein recognition fragments appended on the 5'-ends of the assembled G-quartet: quadruplex containing two anionic residues in each loop (GDGD) displays the highest inhibition potency for ChT, exhibits slow binding inhibition. Quadruplex containing one anionic and one hydrophobic residue (GDGY) strongly inhibits ChT activity, exhibits slow binding inhibition. Quadruplex without tethered loops or containing a peptide loop tethered to a single strand of a sequence that is incapable of forming self-assembled structures, are weak inhibitors | synthetic construct |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
synthetic construct | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-benzoyl-L-tyrosine-p-nitroanilide + H2O | - |
synthetic construct | N-benzoyl-L-tyrosine + p-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-chymotrypsin | - |
synthetic construct |
CHT | - |
synthetic construct |
chymotrypsin | - |
synthetic construct |