Literature summary for 3.4.21.1 extracted from

Fricker, S.P.; Mosi, R.M.; Cameron, B.R.; Baird, I.; Zhu, Y.; Anastassov, V.; Cox, J.; Doyle, P.S.; Hansell, E.; Lau, G.; Langille, J.; Olsen, M.; Qin, L.; Skerlj, R.; Wong, R.S.; Santucci, Z.; McKerrow, J.H.
Metal compounds for the treatment of parasitic diseases (2008), J. Inorg. Biochem., 102, 1839-1845.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(methanethiolato)[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium (V)	-	Homo sapiens
(p-methoxyphenylthiolato-S)[2,6-bis[(mercapto-kappaS)methyl]pyridine-kappaN] oxorhenium(V)	-	Homo sapiens
aceto[2,6-bis[(butylthio-jS)methyl]phenyl-kappaC]-,(SP-4-3)-palladium(II)	-	Homo sapiens
chloro[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium(V)	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O	57 microM, pH 7.8	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
chymotrypsin	-	Homo sapiens
serine protease	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.025	-	above 0.025 mM	Homo sapiens	(p-methoxyphenylthiolato-S)[2,6-bis[(mercapto-kappaS)methyl]pyridine-kappaN] oxorhenium(V)
0.025	-	above 0.025 mM	Homo sapiens	aceto[2,6-bis[(butylthio-jS)methyl]phenyl-kappaC]-,(SP-4-3)-palladium(II)
0.025	-	above 0.025 mM	Homo sapiens	chloro[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium(V)
0.025	-	above 0.025 mM	Homo sapiens	(methanethiolato)[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium (V)

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Release 2023.1 (January 2023)