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Literature summary for 3.4.21.1 extracted from

  • Wysocka, M.; Lesner, A.; Legowska, A.; Ja?kiewicz, A.; Miecznikowska, H.; Rolka, K.
    Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1) (2008), Protein Pept. Lett., 15, 260-264.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-acetyl-L-Phe-Ala-Thr-Pal aldehyde
-
Bos taurus
N-acetyl-L-Phe-Ala-Thr-Phe aldehyde
-
Bos taurus
N-acetyl-L-Phe-Ala-Thr-Phe-(p-NO2) aldehyde
-
Bos taurus
N-acetyl-L-Phe-Ala-Thr-Tyr aldehyde
-
Bos taurus
N-tosyl-L-Phe-Ala-Thr-Phe-(p-NO2) aldehyde
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0009
-
N-benzyloxycarbonyl-L-Phe-Ala-Thr-Phe-(p-NO2)-5-amido-2-nitrobenzoic acid
-
Bos taurus
0.001
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-NO2)-5-amido-2-nitrobenzoic acid
-
Bos taurus
0.0101
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-CN)-5-amido-2-nitrobenzoic acid
-
Bos taurus
0.0177
-
N-benzyloxycarbonyl-L-Phe-Ala-Thr-Tyr-5-amido-2-nitrobenzoic acid
-
Bos taurus
0.0191
-
N-acetyl-L-Phe-Ala-Thr-Phe-5-amido-2-nitrobenzoic acid
-
Bos taurus
0.0598
-
N-acetyl-L-Phe-Ala-Thr-Tyr-5-amido-2-nitrobenzoic acid
-
Bos taurus
0.0635
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-NH2)-5-amido-2-nitrobenzoic acid
-
Bos taurus
0.0891
-
N-acetyl-L-Phe-Ala-Thr-Pal-5-amido-2-nitrobenzoic acid
-
Bos taurus
0.1131
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-COOMe)-5-amido-2-nitrobenzoic acid
-
Bos taurus
0.1203
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-guanidine)-5-amido-2-nitrobenzoic acid
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-L-Phe-Ala-Thr-Pal-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-acetyl-L-Phe-Ala-Thr-Pal + 5-amino-2-nitrobenzoic acid
-
?
N-acetyl-L-Phe-Ala-Thr-Phe-(p-CN)-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-acetyl-L-Phe-Ala-Thr-Phe-(p-CN) + 5-amino-2-nitrobenzoic acid
-
?
N-acetyl-L-Phe-Ala-Thr-Phe-(p-COOH)-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-acetyl-L-Phe-Ala-Thr-Phe-(p-COOH) + 5-amino-2-nitrobenzoic acid
-
?
N-acetyl-L-Phe-Ala-Thr-Phe-(p-COOMe)-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-acetyl-L-Phe-Ala-Thr-Phe-(p-COOMe) + 5-amino-2-nitrobenzoic acid
-
?
N-acetyl-L-Phe-Ala-Thr-Phe-(p-guanidine)-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-acetyl-L-Phe-Ala-Thr-Phe-(p-guanidine) + 5-amino-2-nitrobenzoic acid
-
?
N-acetyl-L-Phe-Ala-Thr-Phe-(p-NH2)-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-acetyl-L-Phe-Ala-Thr-Phe-(p-NH2) + 5-amino-2-nitrobenzoic acid
-
?
N-acetyl-L-Phe-Ala-Thr-Phe-(p-NO2)-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-acetyl-L-Phe-Ala-Thr-Phe-(p-NO2) + 5-amino-2-nitrobenzoic acid
-
?
N-acetyl-L-Phe-Ala-Thr-Phe-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-acetyl-L-Phe-Ala-Thr-Phe + 5-amino-2-nitrobenzoic acid
-
?
N-acetyl-L-Phe-Ala-Thr-Tyr-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-acetyl-L-Phe-Ala-Thr-Tyr + 5-amino-2-nitrobenzoic acid
-
?
N-benzyloxycarbonyl-L-Phe-Ala-Thr-Phe-(p-NO2)-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-benzyloxycarbonyl-L-Phe-Ala-Thr-Phe-(p-NO2) + 5-amino-2-nitrobenzoic acid
-
?
N-benzyloxycarbonyl-L-Phe-Ala-Thr-Tyr-5-amido-2-nitrobenzoic acid + H2O
-
Bos taurus N-benzyloxycarbonyl-L-Phe-Ala-Thr-Tyr + 5-amino-2-nitrobenzoic acid
-
?

Synonyms

Synonyms Comment Organism
alpha-chymotrypsin
-
Bos taurus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.3
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-COOMe)-5-amido-2-nitrobenzoic acid
-
Bos taurus
0.6
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-NO2)-5-amido-2-nitrobenzoic acid
-
Bos taurus
1.8
-
N-benzyloxycarbonyl-L-Phe-Ala-Thr-Phe-(p-NO2)-5-amido-2-nitrobenzoic acid
-
Bos taurus
3
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-CN)-5-amido-2-nitrobenzoic acid
-
Bos taurus
6.1
-
N-acetyl-L-Phe-Ala-Thr-Phe-5-amido-2-nitrobenzoic acid
-
Bos taurus
6.4
-
N-acetyl-L-Phe-Ala-Thr-Pal-5-amido-2-nitrobenzoic acid
-
Bos taurus
6.5
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-guanidine)-5-amido-2-nitrobenzoic acid
-
Bos taurus
16.2
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-NH2)-5-amido-2-nitrobenzoic acid
-
Bos taurus
16.7
-
N-benzyloxycarbonyl-L-Phe-Ala-Thr-Tyr-5-amido-2-nitrobenzoic acid
-
Bos taurus
22.7
-
N-acetyl-L-Phe-Ala-Thr-Tyr-5-amido-2-nitrobenzoic acid
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000112
-
N-tosyl-L-Phe-Ala-Thr-Phe-(p-NO2) aldehyde in Tris-HCl buffer with 20 mM CaCl2, at pH 8.3 Bos taurus
0.000159
-
N-acetyl-L-Phe-Ala-Thr-Phe-(p-NO2) aldehyde in Tris-HCl buffer with 20 mM CaCl2, at pH 8.3 Bos taurus
0.000281
-
N-acetyl-L-Phe-Ala-Thr-Tyr aldehyde in Tris-HCl buffer with 20 mM CaCl2, at pH 8.3 Bos taurus
0.000323
-
N-acetyl-L-Phe-Ala-Thr-Phe aldehyde in Tris-HCl buffer with 20 mM CaCl2, at pH 8.3 Bos taurus
0.003432
-
N-acetyl-L-Phe-Ala-Thr-Pal aldehyde in Tris-HCl buffer with 20 mM CaCl2, at pH 8.3 Bos taurus