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Literature summary for 3.4.21.1 extracted from

  • Nemoda, Z.; Sahin-Toth, M.
    Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen (2006), J. Biol. Chem., 281, 11879-11886.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Trypsin
-
Homo sapiens

Application

Application Comment Organism
medicine pancreatitis treatment Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Trypsinogen + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Preferential cleavage: Tyr-/-, Trp-/-, Phe-/-, Leu-/- specific cleavage of the Phe18-Asp19 peptide bond in the trypsinogen activation peptide and removal of the N-terminal tripeptide Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic juice
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cationic trypsinogen + H2O
-
Homo sapiens ?
-
?
N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine-p-nitroanilide + H2O
-
Homo sapiens p-nitroaniline + N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine
-
?
Trypsinogen + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
caldecrin
-
Homo sapiens
chymotrypsin C
-
Homo sapiens