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Literature summary for 3.4.21.1 extracted from

  • Singh, N.; Jabeen, T.; Sharma, S.; Roy, I.; Gupta, M.N.; Bilgrami, S.; Somvanshi, R.K.; Dey, S.; Perbandt, M.; Betzel, C.; Srinivasan, A.; Singh, T.P.
    Detection of native peptides as potent inhibitors of enzymes. Crystal structure of the complex formed between treated bovine alpha-chymotrypsin and an autocatalytically produced fragment, IIe-Val-Asn-Gly-Glu-Glu-Ala-Val-Pro-Gly-Ser-Trp-Pro-Trp, at 2.2 angstroms resolution (2005), FEBS J., 272, 562-572.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion method Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
AVPGSWPW octapeptide Bos taurus
GAW tripeptide Bos taurus
IVNGEEAVPGSWPW autocatalytically produced 14-residue fragment from a three-phase-partitioning-treated chymotrypsin Bos taurus
TPGVY pentapeptide Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25210
-
MALDI-TOF analysis Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
gel filtration Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzoyl-L-tyrosine ethyl ester + H2O
-
Bos taurus N-benzoyl-L-tyrosine + ethanol
-
?

Synonyms

Synonyms Comment Organism
alpha-chymotrypsin
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000027
-
IVNGEEAVPGSWPW
-
Bos taurus
0.00000099
-
AVPGSWPW
-
Bos taurus
0.000034
-
TPGVY
-
Bos taurus
0.0047
-
GAW
-
Bos taurus