Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxymercuribenzoate | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
brush border membrane | - |
Rattus norvegicus | 31526 | - |
extracellular | - |
Rattus norvegicus | - |
- |
intracellular | - |
Rattus norvegicus | 5622 | - |
lysosome | - |
Rattus norvegicus | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
polyglutamyl-folate + H2O | Rattus norvegicus | gamma-glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine | monoglutamyl folate + glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bile | - |
Rattus norvegicus | - |
duodenal luminal fluid | high activity at pH 4.5 | Rattus norvegicus | - |
duodenum | - |
Rattus norvegicus | - |
enterocyte | - |
Rattus norvegicus | - |
hepatocyte | - |
Rattus norvegicus | - |
ileum | - |
Rattus norvegicus | - |
jejunum | enzyme expression in mucosa | Rattus norvegicus | - |
liver | enzyme expression | Rattus norvegicus | - |
mucosa | duodenal, jejunal, and ileal mucosa | Rattus norvegicus | - |
pancreas | enzyme expression | Rattus norvegicus | - |
pancreatic juice | - |
Rattus norvegicus | - |
serum | - |
Rattus norvegicus | - |
small intestine | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
highest activity in the postprandial duodenal luminal fluid at pH 4.5 | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
polyglutamyl-folate + H2O | - |
Rattus norvegicus | monoglutamyl folate + glutamate | - |
? | |
polyglutamyl-folate + H2O | gamma-glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine | Rattus norvegicus | monoglutamyl folate + glutamate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
folate hydrolase | - |
Rattus norvegicus |
gamma-GH | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 6.5 | 4.5 is the pH optimum, while pH 6.5 is the in vivo reaction temperature | Rattus norvegicus |