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Literature summary for 3.4.19.9 extracted from

  • Cheng, Q.; Cheng, C.; Crews, K.R.; Ribeiro, R.C.; Pui, C.H.; Relling, M.V.; Evans, W.E.
    Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells (2006), Am. J. Hum. Genet., 79, 264-274.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
GGH activity is directly related to GGH messenger RNA expression in acute lymphoblastic leukemia cells of patients with a wild-type germline GGH genotype, identification of two CpG islands, CpG1 and CpG2, in the region extending from the GGH promoter through the first exon and into intron 1, methylation of both CpG islands in the GGH promoter is associated with significantly reduced GGH mRNA expression and catalytic activity and with significantly higher accumulation of MTX polyglutamates in the cells, methylation of CpG1 is leukemia-cell specific and has a pronounced effect on GGH expression, whereas methylation of CpG2 is common in leukemia cells and normal leukocytes but does not significantly alter GGH expression, expression analysis, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
folate + H2O Homo sapiens
-
pteroate + glutamate
-
?
additional information Homo sapiens GGH catalyzes degradation of the active polyglutamates of natural folates and the antifolate methotrexate ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphoblastic leukemia cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
folate + H2O
-
Homo sapiens pteroate + glutamate
-
?
methotrexate + H2O
-
Homo sapiens ?
-
?
additional information GGH catalyzes degradation of the active polyglutamates of natural folates and the antifolate methotrexate Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
GGH
-
Homo sapiens