Cloned (Comment) | Organism |
---|---|
GGH activity is directly related to GGH messenger RNA expression in acute lymphoblastic leukemia cells of patients with a wild-type germline GGH genotype, identification of two CpG islands, CpG1 and CpG2, in the region extending from the GGH promoter through the first exon and into intron 1, methylation of both CpG islands in the GGH promoter is associated with significantly reduced GGH mRNA expression and catalytic activity and with significantly higher accumulation of MTX polyglutamates in the cells, methylation of CpG1 is leukemia-cell specific and has a pronounced effect on GGH expression, whereas methylation of CpG2 is common in leukemia cells and normal leukocytes but does not significantly alter GGH expression, expression analysis, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
folate + H2O | Homo sapiens | - |
pteroate + glutamate | - |
? | |
additional information | Homo sapiens | GGH catalyzes degradation of the active polyglutamates of natural folates and the antifolate methotrexate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphoblastic leukemia cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
folate + H2O | - |
Homo sapiens | pteroate + glutamate | - |
? | |
methotrexate + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | GGH catalyzes degradation of the active polyglutamates of natural folates and the antifolate methotrexate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GGH | - |
Homo sapiens |