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Literature summary for 3.4.19.9 extracted from

  • Galivan, J.; Ryan, T.J.; Chave, K.; Rhee, M.; Yao, R.; Yin, D.
    Glutamyl hydrolase: pharmacological role and enzymatic characterization (2000), Pharmacol. Ther., 85, 207-215.
    View publication on PubMed
Search for more literature for 3.4.19.9

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pteroylpolyglutamate + H2O Homo sapiens the enzyme is responsible for the intracellular cleavage of poly-gamma-glutamates ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methotrexate triglutamate + H2O
-
 Homo sapiens methotrexate monoglutamate + methotrexate diglutamate + glutamate
-
 ?
additional information the enzyme is a cysteine peptidase Homo sapiens ?
-
 ?
pteroylpolyglutamate + H2O the enzyme is responsible for the intracellular cleavage of poly-gamma-glutamates Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5 6
-
 Homo sapiens