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Literature summary for 3.4.19.9 extracted from

  • Chandler, C.J.; Wang, T.T.Y.; Halsted, C.H.
    Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization (1986), J. Biol. Chem., 261, 928-933.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NaF
-
Homo sapiens
p-Aminobenzoate 0.1 mM: no inhibition, 30% inhibition at 1.0 mM Homo sapiens
substituted and reduced pteroylglutamate 0.1 mM: not, 30% inhibition at 1.0 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00055
-
Pteroyltriglutamate
-
Homo sapiens
0.0006
-
Pteroylheptaglutamate
-
Homo sapiens
0.0006
-
pteroyldiglutamate
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ slight activation Homo sapiens
Ca2+ activation Homo sapiens
Cd2+ slight activation Homo sapiens
Fe2+ slight activation Homo sapiens
Mg2+ slight activation Homo sapiens
Mg2+ activation Homo sapiens
Mn2+ slight activation Homo sapiens
Mn2+ activation Homo sapiens
Ni2+ slight activation Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
115000
-
x * 145000 + x * 115000, SDS/urea PAGE Homo sapiens
145000
-
x * 145000 + x * 115000, SDS/urea PAGE Homo sapiens
700000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
jejunum mucosal brush-border Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pteroyldiglutamate + H2O
-
Homo sapiens ?
-
?
pteroylheptaglutamate + H2O
-
Homo sapiens ?
-
?
pteroyltriglutamate + H2O
-
Homo sapiens ?
-
?
pteroyltriglutamate + H2O
-
Homo sapiens pteroylglutamate + glutamate
-
?

Subunits

Subunits Comment Organism
? x * 145000 + x * 115000, SDS/urea PAGE Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
-
Homo sapiens

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
30
-
about 25% of activity maximum at 30°C and 80°C Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
65
-
up to, for at least 90 min Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
4 7 about 45% of activity maximum at pH 4 and pH 7 Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.5
-
stable at pH 6.5 and above, 90 min Homo sapiens