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Literature summary for 3.4.19.9 extracted from

  • Elsenhans, B.; Ahmad, O.; Rosenberg, I.H.
    Isolation and characterization of pteroylpolyglutamate hydrolase from rat intestinal mucosa (1984), J. Biol. Chem., 259, 6364-6368.
    View publication on PubMed
Search for more literature for 3.4.19.9

Inhibitors

Inhibitors Comment Organism Structure
Dextran sulfate
-
 Rattus norvegicus
heparin
-
 Rattus norvegicus
p-hydroxymercuribenzoate
-
 Rattus norvegicus
poly-gamma-glutamic acid
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00021
-
 Pteroylheptaglutamate
-
 Rattus norvegicus
0.00067
-
 Pteroyltriglutamate
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
affinity chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
intestine mucosa Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
polyglutamylfolate + H2O endopeptidase-like mode of action Rattus norvegicus ?
-
 ?
pteroylheptaglutamate + H2O
-
 Rattus norvegicus ? pteroylmonoglutamate + hexaglutamyl peptide ?
pteroyltriglutamate + H2O
-
 Rattus norvegicus ?
-
 ?
pteroyltriglutamate + H2O
-
 Rattus norvegicus pteroylglutamate + glutamate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
-
 Rattus norvegicus