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Literature summary for 3.4.19.6 extracted from

  • Scharfmann, R.; Morgat, J.L.; Aratan-Spire, S.
    Presence of a particulate thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity in rat liver (1989), Neuroendocrinology, 49, 442-448.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
thyrotropin-releasing hormone
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
particle-bound the physicochemical properties are distinct from the soluble enzyme Rattus norvegicus
-
-
soluble the physicochemical properties are distinct from the particulate enzyme Rattus norvegicus
-
-
synaptosome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thyroliberin + H2O Rattus norvegicus involved in the conversion of thyrotropin-releasing hormone into histidyl-proline diketopiperazine ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thyroliberin + H2O i.e. pyroglutamyl-His-Pro-NH2, thyrotropin-releasing hormone Rattus norvegicus pyroglutamic acid + His-Pro-NH2 pyroglutamic acid + histidyl-proline diketopiperazine ?
thyroliberin + H2O involved in the conversion of thyrotropin-releasing hormone into histidyl-proline diketopiperazine Rattus norvegicus ?
-
?