Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2 | - |
Rattus norvegicus | |
p-Glu-Asn-Pro-7-amido-4-methylcoumarin | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q10836 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
medial septum | 12 to 14% of cell profiles express pyroglutamyl peptidase II mRNA in the medial septum-diagonal band of Broca, in this region the specific activity of the enzyme is relatively high. Injection of the pyroglutamyl peptidase II inhibitor p-Glu-Asn-Pro-7-amido-4-methylcoumarin into the medial septum enhances the effect of thyrotropin-releasing hormone. The injection of a phosphinic thyrotropin-releasing hormone analog, a higher affinity inhibitor of pyroglutamyl peptidase II, diminishes the duration of ethanol-induced loss of righting reflex by itself | Rattus norvegicus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | in the medial septum pyroglutamyl peptidase II activity may limit thyrotropin-releasing hormone action, presumably by reducing the concentration of thyrotropin-releasing hormone in the extracellular fluid around cells coexpressing pyroglutamyl peptidase II and thyrotropin-releasing hormone-receptor 1 | Rattus norvegicus |