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Literature summary for 3.4.19.6 extracted from
- Synthesis of the phosphinic analogue of thyrotropin releasing hormone (2008), J. Org. Chem., 73, 8591-8593.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | pyroglutamyl peptidase II inhibitors may be used to enhance the therapeutic actions of thyrotropin releasing hormone | Mammalia |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Glp-PSI[P(O)(OH)CH2]-His-Pro-NH2 | phosphinic analogue of thyrotropin releasing hormone, ED50 170 nM | Mammalia |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | - |
Mammalia | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thyrotropin releasing hormone + H2O | - |
Mammalia | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PPII | - |
Mammalia |
| pyroglutamyl peptidase II | - |
Mammalia |
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