Application | Comment | Organism |
---|---|---|
medicine | inhibitors of the enzyme may be used to enhance the therapeutic actions of TRH and to investigate the functions of thyrotropin-releasing hormone and pyroglutamyl-peptidase II | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-pyroglutamyl-Asn-Pro-NH2 | inhibition is fully reversible | Sus scrofa | |
pyroglutamyl-Asn-Pro-7-amido-4-methyl coumarin | - |
Sus scrofa | |
pyroglutamyl-Asn-Pro-NH2 | - |
Sus scrofa | |
pyroglutamyl-Gln-Pro-NH2 | - |
Sus scrofa | |
pyroglutamyl-Gly-Pro-NH2 | inhibition is fully reversible | Sus scrofa | |
pyroglutamyl-homoprolyl-Pro-NH2 | - |
Sus scrofa | |
pyroglutamyl-L-alpha-phenylglycyl-Pro-NH2 | - |
Sus scrofa | |
pyroglutamyl-Trp-Pro-NH2 | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0035 | - |
pyroglutamyl-His-Pro-7-amido-4-methylcoumarin | pH 7.5, 37°C | Sus scrofa | |
0.015 | - |
L-pyroglutamyl-L-Tyr-L-Pro-NH2 | pH 7.5, 37°C | Sus scrofa | |
0.034 | - |
pyroglutamyl-thienylalanyl-Pro-NH2 | pH 7.5, 37°C | Sus scrofa | |
0.035 | - |
pyroglutamyl-His-Pro-NH2 | pH 7.5, 37°C | Sus scrofa | |
0.055 | - |
pyroglutamyl-Phe-Pro-NH2 | pH 7.5, 37°C | Sus scrofa | |
0.311 | - |
pyroglutamyl-His-Pro-OH | pH 7.5, 37°C | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
enzyme from brain | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-pyroglutamyl-L-Tyr-L-Pro-NH2 + H2O | - |
Sus scrofa | L-pyroglutamate + L-Tyr-L-Pro-NH2 | - |
? | |
additional information | moderately bulky, uncharged P1' residues preferentially bind to the enzyme | Sus scrofa | ? | - |
? | |
pyroglutamyl-His-Pro-7-amido-4-methylcoumarin + H2O | - |
Sus scrofa | pyroglutamate + His-Pro-7-amido-4-methylcoumarin | - |
? | |
pyroglutamyl-His-Pro-NH2 + H2O | - |
Sus scrofa | pyroglutamate + His-Pro-NH2 | - |
? | |
pyroglutamyl-His-Pro-OH + H2O | - |
Sus scrofa | pyroglutamate + His-Pro-OH | - |
? | |
pyroglutamyl-Phe-Pro-NH2 + H2O | - |
Sus scrofa | pyroglutamate + Phe-Pro-NH2 | - |
? | |
pyroglutamyl-Phe-Pro-OH + H2O | - |
Sus scrofa | pyroglutamate + Phe-Pro-OH | - |
? | |
pyroglutamyl-thienylalanyl-Pro-NH2 + H2O | - |
Sus scrofa | pyroglutamate + thienylalanyl-Pro-NH2 | - |
? | |
pyroglutamyl-Tyr-Pro-OH + H2O | - |
Sus scrofa | pyroglutamate + Tyr-Pro-OH | - |
? | |
thyroliberin + H2O | - |
Sus scrofa | pyroglutamic acid + His-Pro-NH2 | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00097 | - |
pyroglutamyl-Asn-Pro-7-amido-4-methyl coumarin | pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin | Sus scrofa | |
0.0175 | - |
pyroglutamyl-Asn-Pro-NH2 | pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin | Sus scrofa | |
0.069 | - |
pyroglutamyl-Gln-Pro-NH2 | pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin | Sus scrofa | |
0.232 | - |
pyroglutamyl-Trp-Pro-NH2 | pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin | Sus scrofa | |
0.356 | - |
pyroglutamyl-L-alpha-phenylglycyl-Pro-NH2 | pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin | Sus scrofa | |
0.5 | - |
pyroglutamyl-homoprolyl-Pro-NH2 | pH 7.5, 37°C, hydrolysis of pyroglutamyl-His-Pro-7-amido-4-methylcoumarin | Sus scrofa |