Any feedback?
Literature summary for 3.4.19.6 extracted from
- Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme (1989), Neurochem. Int., 15, 81-89.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| metal chelators | - |
Oryctolagus cuniculus | |
| additional information | no inhibition by aspartyl protease inhibitors; no inhibition by cysteine protease inhibitors; no inhibition by serine protease inhibitors | Oryctolagus cuniculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Oryctolagus cuniculus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 230000 | - |
gel filtration | Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thyroliberin + H2O | Oryctolagus cuniculus | may control the biological activity of the neuronally released thyrotropin | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no hydrolysis of pyroglutamyl-His decapeptide LHRH | Oryctolagus cuniculus | ? | - |
? | |
| additional information | no hydrolysis of pyroglutamyl-His | Oryctolagus cuniculus | ? | - |
? | |
| additional information | no hydrolysis of Phe3-thyrotropin | Oryctolagus cuniculus | ? | - |
? | |
| additional information | no hydrolysis of ring opened Glu1-thyrotropin | Oryctolagus cuniculus | ? | - |
? | |
| additional information | no hydrolysis of pyroglutamyl-His-Pro-Ala naphthylamide | Oryctolagus cuniculus | ? | - |
? | |
| additional information | no hydrolysis of pyroglutamyl-His bond of the dipeptide pyroglutamyl-His naphthylamide | Oryctolagus cuniculus | ? | - |
? | |
| pyroglutamyl-His-tripeptidyl naphthylamides + H2O | - |
Oryctolagus cuniculus | pyroglutamate + His-tripeptidyl naphthylamides | - |
? | |
| thyroliberin + H2O | may control the biological activity of the neuronally released thyrotropin | Oryctolagus cuniculus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
broad pH-optimum in the neutral range | Oryctolagus cuniculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
