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Literature summary for 3.4.19.14 extracted from

  • Wickham, S.; West, M.; Cook, P.; Hanigan, M.
    Gamma-glutamyl compounds: Substrate specificity of gamma-glutamyl transpeptidase enzymes (2011), Anal. Biochem., 414, 208-214.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.19.14

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
serine-borate 8fold more potent in inhibiting GGT1 than in inhibiting GGT5 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0102
-
 leukotriene C4 in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C Homo sapiens
0.0148
-
 S-(4-nitro-benzyl)glutathione in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C Homo sapiens
0.0182
-
 S-Methylglutathione in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C Homo sapiens
0.0751
-
 glutathione sulfonic acid in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C Homo sapiens
0.105
-
 reduced glutathione in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C Homo sapiens
0.426
-
 oxidized glutathione in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione sulfonic acid + H2O + glycylglycine
-
 Homo sapiens ? + gamma-glutamyl-glycylglycine
-
 ?
leukotriene C4 + H2O
-
 Homo sapiens leukotriene D4 + L-glutamate
-
 ?
additional information no activity with gamma-glutamyl leucine Homo sapiens ?
-
 ?
oxidized glutathione + H2O + glycylglycine
-
 Homo sapiens ? + gamma-glutamyl-glycylglycine
-
 ?
reduced glutathione + H2O + glycylglycine
-
 Homo sapiens ? + gamma-glutamyl-glycylglycine
-
 ?
S-(4-nitro-benzyl)glutathione + H2O + glycylglycine
-
 Homo sapiens ? + gamma-glutamyl-glycylglycine
-
 ?
S-methylglutathione + H2O + glycylglycine
-
 Homo sapiens ? + gamma-glutamyl-glycylglycine
-
 ?

Synonyms

Synonyms Comment Organism
gamma-glutamyl leukotrienase
-
 Homo sapiens
GGT5 isoform B Homo sapiens