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Literature summary for 3.4.19.12 extracted from

  • Chen, F.; Sugiura, Y.; Myers, K.G.; Liu, Y.; Lin, W.
    Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction (2010), Proc. Natl. Acad. Sci. USA, 107, 1636-1641.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information construction of UCH-L1 knockout mice by targeted deletion of the UCH-L1 gene, in the absence of UCH-L1, synaptic transmission at the neuromuscular junctions is markedly impaired and it leads to ultrastructural defects of presynaptic nerve terminals at the neuromuscular junctions. UCH-L1 null mutation leads to progressive paralysis and premature death in mice, external phenotype and survival rate, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
brain UCH-L1 is one of the most abundant proteins in the mammalian brain Mus musculus
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peripheral nervous system including sensory and motor nerves Mus musculus
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Synonyms

Synonyms Comment Organism
ubiquitin carboxyl-terminal hydrolase L1
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 Mus musculus
UCH-L1
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 Mus musculus

General Information

General Information Comment Organism
malfunction in the absence of UCH-L1, synaptic transmission at the neuromuscular junctions is markedly impaired. Loss of normal UCH-L1 activity may result in neurodegeneration in the peripheral nervous system Mus musculus
physiological function role of UCH-L1 in synaptic function in the brain, overview Mus musculus