Cloned (Comment) | Organism |
---|---|
expression of HA-tagged wild-type and mutant enzymes in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C90S | a UCH L1 mutant, that shows no binding to beta-catenin | Homo sapiens |
H161D | a UCH L1 mutant, that shows no binding to beta-catenin | Homo sapiens |
additional information | UCH L1 silencing with siRNAs leads to accumulation of beta-catenin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | UCH L1 forms endogenous complexes with beta-catenin and stabilizes it. The expression and deubiquitinating activity of UCHL1 are required for its own basic promoter activity, therefore UCH L1 up-regulates its expression by activation of the oncogenic beta-catenin/TCF signaling in transformed cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
swiss mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
KR-4 cell | a B lymphoblastoid cell line | Homo sapiens | - |
NIH-3T3 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UCH L1 forms endogenous complexes with beta-catenin and stabilizes it. The expression and deubiquitinating activity of UCHL1 are required for its own basic promoter activity, therefore UCH L1 up-regulates its expression by activation of the oncogenic beta-catenin/TCF signaling in transformed cells | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin C-terminal hydrolase L1 | - |
Mus musculus |
ubiquitin C-terminal hydrolase L1 | - |
Homo sapiens |
UCH L1 | - |
Mus musculus |
UCH L1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | treatment with LiCl induces UCH L1 expression in 3T3 cells, no induction by TCF-4, but synergistic effects of TCF-4 and LiCl, TCF4 binds to the endogenous uchl1 promoter | up |
General Information | Comment | Organism |
---|---|---|
physiological function | UCH L1 up-regulates beta-catenin/TCF signaling. UCH L1 forms endogenous complexes with beta-catenin, stabilizes it and up-regulates beta-catenin/TCF-dependent transcription. The deubiquitinating activity of UCH L1 is required for TCF4 transcriptional activity, overview | Homo sapiens |