Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ethyl 1-[N-(4-methylphenyl)-N-(methylsulfonyl)alanyl]-4-piperidinecarboxylate | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(1,3-benzodioxol-5-ylmethyl)-4-(4-([(4-chlorophenyl)thio]methyl)benzoyl) piperazine | slight inhibition of UCH-L1 | Homo sapiens | |
2-([4-(2-furylmethyl)-5-(2-thienylmethyl)-4H-1,2,4-triazol-3-yl]thio)-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide | - |
Homo sapiens | |
2-[(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio]-N-(4-methyl-2-pyridinyl)acetamide | - |
Homo sapiens | |
4-([benzyl(methyl)amino]sulfonyl)-N-[5-(benzylthio)-1,3,4-thiadiazol-2-yl]benzamide | - |
Homo sapiens | |
8-[(1H-benzimidazol-2-ylmethyl)sulfanyl]-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine | - |
Homo sapiens | |
additional information | kinetics and inhibitor docking study using crystal structure data of PDB code 2ETL, overview. No or poor inhibition by 3-methyl-8-(4-methyl-1-piperazinyl)-7-(3-phenylpropyl)-3,7-dihydro-1Hpurine-2,6-dione, 1-(4-methoxyphenyl)-4-([3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl)piperazine, N1-cyclopropyl-N2-(4-ethoxyphenyl)-N2-[(4-methylphenyl)sulfonyl]glycinamide, N-[6-((2-[(4-chlorophenyl)thio]acetyl)amino)-1,3-benzothiazol-2-yl]butanamide and N-1,3-benzothiazol-2-yl-2-([5-(4-morpholinylmethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio)acetamide | Homo sapiens | |
N,N'-(oxydi-4,1-phenylene)dibenzenesulfonamide | slight inhibition of UCH-L1 | Homo sapiens | |
N,N'-4,4'-biphenyldiylbis(4-ethylbenzenesulfonamide) | strong inhibition of UCH-L1 | Homo sapiens | |
N-(2-[(6,7-dimethoxy-1-isoquinolinyl)methyl]-4,5-dimethoxyphenyl)-4-(2-oxo-1-pyrrolidinyl)benzenesulfonamide | slight inhibition of UCH-L1 | Homo sapiens | |
N-(3,6-dichloro-2-pyridinyl)-N'-([(4,6-diphenyl-2-pyrimidinyl)amino]carbonyl)sulfamide | - |
Homo sapiens | |
N-(4-([(4-ethoxyphenyl)amino]sulfonyl)phenyl)-2-naphthalenesulfonamide | slight inhibition of UCH-L1 | Homo sapiens | |
N-(4-([(4-methylphenyl)amino]sulfonyl)phenyl)-2-phenyl-2-(phenylthio)acetamide | slight inhibition of UCH-L1 | Homo sapiens | |
N-[2-(4-benzyl-1-piperazinyl)-2-oxoethyl]-N-(3-methylphenyl)benzenesulfonamide | slight inhibition of UCH-L1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09936 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant UCH-L1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquitin-4-methylcoumarine 7-amide + H2O | - |
Homo sapiens | ubiquitin + 7-amino-4-methylcoumarine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin-C-terminal hydrolase L1 | - |
Homo sapiens |
UCH-L1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.015 | - |
- |
Homo sapiens | N,N'-4,4'-biphenyldiylbis(4-ethylbenzenesulfonamide) |
General Information | Comment | Organism |
---|---|---|
malfunction | the hydrolase activity of UCH-L1 is implicated in Alzheimer's disease and cancer invasion | Homo sapiens |