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Literature summary for 3.4.19.12 extracted from

  • Henderson, M.J.; Vij, N.; Zeitlin, P.L.
    Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation (2010), J. Biol. Chem., 285, 11314-11325.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.19.12

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane UCH-L1 is membrane-associated and co-localizes with the ribosomal subunit RPS6 and the ER retention signal KDEL. UCH-L1 is partially co-localized to the site of CFTR protein synthesis Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens UCH-L1 is a deubiquitinating enzyme. UCH-L1 increases the synthesis of cystic fibrosis transmembrane conductance regulator, CFTR, but has little effect on the rate of post-translational degradation ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
IB3-1 cell a bronchial epithelial cell line, the cells show increased UCH-L1 expression, overview Homo sapiens
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additional information the deubiquitinating enzyme, ubiquitin C-terminal hydrolase-L1, is highly expressed in cystic fibrosis airway epithelial cells in vitro and in vivo Homo sapiens
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S9 cell a bronchial epithelial cell line, the cells show increased UCH-L1 expression, overview Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UCH-L1 is a deubiquitinating enzyme. UCH-L1 increases the synthesis of cystic fibrosis transmembrane conductance regulator, CFTR, but has little effect on the rate of post-translational degradation Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
ubiquitin C-terminal hydrolase-L1
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 Homo sapiens
UCH-L1
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 Homo sapiens

General Information

General Information Comment Organism
malfunction elevation in UCH-L1 in cystic fibrosis cells represents a cellular adaptation to counterbalance excessive proteasomal degradation Homo sapiens
physiological function UCH-L1 is a deubiquitinating enzyme. UCH-L1 is a deubiquitinating enzyme. UCH-L1 increases the synthesis of cystic fibrosis transmembrane conductance, and endogenous UCH-L1 expression is positively correlated with CFTR biogenesis Homo sapiens