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Literature summary for 3.4.19.12 extracted from
- Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation (2009), Cell. Signal., 21, 1513-1521.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GST-tagged wild-type and mutant enzymes in HEK-293 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| I93M | naturally occuring mutation of Uch-L1 involved in the Parkinson's disease | Homo sapiens |
| S18Y | naturally occuring mutation of Uch-L1 involved in the Huntington's disease | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | interaction of the ubiquitin carboxyl terminal esterase L1 with alpha2-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation. Uch-L1 binds specifically to the third intracellular loop of alpha2A adrenergic receptor, but also to the respective loops of adrenergic receptors alpha2B, alpha2C, and beta2, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P09936 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neuron | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | interaction of the ubiquitin carboxyl terminal esterase L1 with alpha2-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation. Uch-L1 binds specifically to the third intracellular loop of alpha2A adrenergic receptor, but also to the respective loops of adrenergic receptors alpha2B, alpha2C, and beta2, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ubiquitin carboxyl terminal esterase L1 | - |
Homo sapiens |
| ubiquitin carboxyl-terminal hydrolase-L1 | - |
Homo sapiens |
| UCH-L1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | Uch-L1 is associated with Parkinson's disease, as alpha2-adrenergic receptor interacting protein. alpha2-Adrenergic receptor agonist-mediated activation of p44/42MAP kinase is drastically decreased in the presence of Uch-L1. Stimulation of recombinantly UCH-L1 expressing HEK-293 cells prior lysis with norepinephrine, yohimbine, phentolamine or moxonidine does also not significantly affect the interaction, as well as co-transfection of arrestin-3 or spinophilin-(Phe151-Lys446) | Homo sapiens |
| physiological function | Uch-L1 is involved in controling alpha2-adrenergic receptor receptor function and trafficking, it binds preferentially to the alpha2A-adrenergic receptor subtype and only with less affinity to alpha2B-adrenergic receptor and alpha2C-adrenergic receptor, specific interaction in vivo, mechanism, overview | Homo sapiens |
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