Literature summary for 3.4.19.12 extracted from

Ichikawa, T.; Li, J.; Dong, X.; Potts, J.D.; Tang, D.Q.; Li, D.S.; Cui, T.
Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation (2010), Biochem. Biophys. Res. Commun., 391, 852-856.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q00981	adult Sprague-Dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	vascular smooth muscle cells. UCH-L1 is up-regulated in injured arteries	Rattus norvegicus	-
vascular smooth muscle cell	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
ubiquitin carboxyl terminal hydrolase L1	-	Rattus norvegicus
UCH-L1	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	TNFalpha up-regulates UCH-L1via a translational regulation to inhibit ERK activity, thereby providing a negative feedback to control its growth promoting signaling in vascular smooth muscle cells	up

General Information

General Information	Comment	Organism
malfunction	UCH-L1 is up-regulated in injured arteries, via posttranscriptional regulation, and local gene delivery of UCH-L1 inhibited vascular lesion formation with suppression of inflammatory responses in vasculature. ERK activation also contributes to the growth inhibitory effect of UCH-L1 in TNFalpha-inflamed vascular smooth muscle cells	Rattus norvegicus
physiological function	UCH-L1 appears to be a multi-functional protein and exerts cell type and/or tissue specific actions	Rattus norvegicus

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Release 2023.1 (January 2023)