Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RNAi | suppressing UCH-L1 expression by RNAi significantly suppresses the invasion in vitro and in vivo, and the activation of Akt and downstream mitogen activates protein kinases c-Jun N-terminal kinases and p38, but not ERK | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | UCH-L1 is a key molecule to regulate tumor-cell invasion by upstream activation of Akt. Expression of UCH-L1 in tumor cells enhances their invasive potential in vitro and in vivo. UCH-L1 changes cell morphology by regulating cell adhesion through Akt-mediated pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09936 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | UCH-L1 is highly expressed in H157 cells, having high invasive potential. In Akt-negative mutants, overexpression of UCH-L1 does not affect the invasion and migration capability of H157 cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UCH-L1 is a key molecule to regulate tumor-cell invasion by upstream activation of Akt. Expression of UCH-L1 in tumor cells enhances their invasive potential in vitro and in vivo. UCH-L1 changes cell morphology by regulating cell adhesion through Akt-mediated pathway | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin C-terminal hydrolase-L1 | - |
Homo sapiens |
UCH-L1 | - |
Homo sapiens |