Literature summary for 3.4.19.12 extracted from

Sekiguchi, S.; Kwon, J.; Yoshida, E.; Hamasaki, H.; Ichinose, S.; Hideshima, M.; Kuraoka, M.; Takahashi, A.; Ishii, Y.; Kyuwa, S.; Wada, K.; Yoshikawa, Y.
Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy (2006), Am. J. Pathol., 169, 1722-1729.

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Application

Application	Comment	Organism
medicine	UCH-L1 is selectively expressed on the plasma membrane of mouse ova, where it may regulate membrane penetration by spermatozoa. The unique expression patterns of UCH-L1 and UCH-L3 suggest that these proteins have distinct functions during oogenesis and embryogenesis. UCH-L1 functions in the polyspermy block during mammalian fertilization	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	UCH-L1-deficient ova of gad female mice have a significantly increased rate of polyspermy in in vitro fertilization assays, although the rate of fertilization does not differ significantly from wild-type mice. Litter size of gad female mice is significantly reduced compared with wild-type mice	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	UCH-L3 concentrated in the cytoplasm of oocytes and developing embryos	Mus musculus	5737	-
plasma membrane	UCH-L1 most abundant at the plasma membrane of oocytes in developing follicles and in developing embryos	Mus musculus	5886	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	BDF1, gad (CBA/RFM) and Uchl3 knockout (C57BL/6J) female and male mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blastocyst	UCH-L1 present in the outer layer cells of the trophectoderm. UCH-L3 present in the inner cells	Mus musculus	-
embryo	UCH-L1 and UCH-L3 present during all of the embryonic stages. UCH-L1 is essentially constant in all cases, but the level of UCH-L3 is lower in the blastocyst stage. Developing embryos of gad and Uchl3 knockout mice are negative for UCH-L1 and UCH-L3	Mus musculus	-
oocyte	UCH-L1 and UCH-L3 present in mature oocytes. Oocytes of gad and Uchl3 knockout mice ovaries are negative for UCH-L1 and UCH-L3, respectively	Mus musculus	-
ovary	UCH-L1 and UCH-L3 are expressed in ovaries during proestrus, estrus, metestrus, and diestrus. Both proteins are present at all estrous cycle stages in wild-type mice. UCH-L1 is absent from gad ovaries and UCH-L3 from Uchl3 knockout ovaries	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
ubiquitin carboxyl-terminal hydrolase L1	-	Mus musculus
UCH-L1	-	Mus musculus
UCH-L3	-	Mus musculus

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Release 2023.1 (January 2023)