Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.19.12 extracted from

  • Shen, H.; Sikorska, M.; Leblanc, J.; Walker, P.R.; Liu, Q.Y.
    Oxidative stress regulated expression of ubiquitin carboxyl-terminal hydrolase-L1: role in cell survival (2006), Apoptosis, 11, 1049-1059.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens UCHL1 is an essential gene in cell survival under normal growth conditions and against oxidative stress ?
-
?
additional information Homo sapiens UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P09936
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NT2/D1 cell
-
Homo sapiens
-
NT2/D1 cell down regulation of UCHL1 is detected immediately after oxygen-glucose deprivation treatment and its expression is subsequently restored and increased 6 h after oxygen-glucose deprivation treatment as well as during reoxygenation. A lower level of UCHL1 is detected only in apoptotic cells with severe loss of mitochondrial membrane potential. Down-regulation of endogenous UCHL1 by antisense cDNA in mouse N2a neuroblastoma cells increased the cellย’s sensitivity to oxygen-glucose deprivation. This down-regulation of endogenous UCHL1 leads to the accumulation of p27, suggesting that UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UCHL1 is an essential gene in cell survival under normal growth conditions and against oxidative stress Homo sapiens ?
-
?
additional information UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ubiquitin carboxyl-terminal hydrolase-L1
-
Homo sapiens
UCHL1
-
Homo sapiens