Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.19.12 extracted from

  • Choi, J.; Levey, A.I.; Weintraub, S.T.; Rees, H.D.; Gearing, M.; Chin, L.S.; Li, L.
    Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases (2004), J. Biol. Chem., 279, 13256-13264.
    View publication on PubMed
Search for more literature for 3.4.19.12

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the full length UCH-L1 is a de-ubiquinating enzyme in brain, and a major target of oxidative damage in Alzheimer's diesease and Parkinson's disease brains, modified by cysteine and methionine oxidation and carbonyl formation ?
-
 ?
additional information Homo sapiens oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinsons and Alzheimers diseases ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 3 isozymes of UCH-L1
-
Homo sapiens P09936
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain frontal cortex of healthy, Alzheimer's disease, and Parkinson's disease brains, 3 isozymes of UCH-L1, UCH-L1 is down-regulated in Alzheimer's diesease and Parkinson's disease brains Homo sapiens
-
brain oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinsons and Alzheimers diseases Homo sapiens
-
additional information proteomic analysis Homo sapiens
-
neurofibrillary tangle associated to Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the full length UCH-L1 is a de-ubiquinating enzyme in brain, and a major target of oxidative damage in Alzheimer's diesease and Parkinson's disease brains, modified by cysteine and methionine oxidation and carbonyl formation Homo sapiens ?
-
 ?
additional information oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinsons and Alzheimers diseases Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ubiquitin carboxyl-terminal hydrolase L1
-
 Homo sapiens
UCH-L1
-
 Homo sapiens