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Literature summary for 3.4.19.12 extracted from

  • Kwon, J.; Wang, Y.L.; Setsuie, R.; Sekiguchi, S.; Sato, Y.; Sakurai, M.; Noda, M.; Aoki, S.; Yoshikawa, Y.; Wada, K.
    Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis (2004), Am. J. Pathol., 165, 1367-1374.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information gad, i.e. gracile axonal dystrophy, mice testis lack isozyme UCH-L1 and are resistant to cryptorchid stress-related injury, the show reduced ubiquitin levels, uchl3 knockout mice show profound testicular atrophy and apoptotic germ cell loss after cryptorchid injury, but unaltered ubiquitin levels compared to wild-type mice, testicular phenotype of mutant mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the closely related isozymes UCH-L1 and UCH-L3 function as reciprocal modulators of germ cell apoptosis in cryptorchid testis ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 genes uchl1 and uchl3, C57BL/6J and gad, i.e. gracile axonal dystrophy, mice
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Mus musculus Q9R0P9
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Source Tissue

Source Tissue Comment Organism Textmining
germ cell
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 Mus musculus
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testis cryptorchid and healthy Mus musculus
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testis absence of UCH-L1 causes resistance to cryptorchid-induced testicular germ cell apoptosis. UCH-L1 and UXH-L3 have reciprocal functions, with respect to mediating injury after experimental cryptorchidism Mus musculus
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testis absence of UCH-L3 promotes germ cell apoptosis after cryptorchid injury. UCH-L1 and UXH-L3 have reciprocal functions, with respect to mediating injury after experimental cryptorchidism Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the closely related isozymes UCH-L1 and UCH-L3 function as reciprocal modulators of germ cell apoptosis in cryptorchid testis Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
More the enzymes belong to the UCH family Mus musculus
ubiquitin C-terminal hydrolase
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 Mus musculus
UCH
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 Mus musculus
UCH-L1
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 Mus musculus
UCH-L3
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 Mus musculus