Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | active-site thiol is very sensitive to oxidation and requires reductants | Drosophila melanogaster | |
2-mercaptoethanol | active-site thiol is very sensitive to oxidation and requires reductants | Homo sapiens | |
2-mercaptoethanol | active-site thiol is very sensitive to oxidation and requires reductants | Rattus norvegicus | |
2-mercaptoethanol | active-site thiol is very sensitive to oxidation and requires reductants | Bos taurus | |
DTT | active-site thiol is very sensitive to oxidation and requires reductants | Drosophila melanogaster | |
DTT | active-site thiol is very sensitive to oxidation and requires reductants | Homo sapiens | |
DTT | active-site thiol is very sensitive to oxidation and requires reductants | Rattus norvegicus | |
DTT | active-site thiol is very sensitive to oxidation and requires reductants | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquitin-peptide + H2O | Drosophila melanogaster | - |
? | - |
? | |
ubiquitin-peptide + H2O | Homo sapiens | - |
? | - |
? | |
ubiquitin-peptide + H2O | Rattus norvegicus | - |
? | - |
? | |
ubiquitin-peptide + H2O | Bos taurus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
UCH-L1, SwissProt: P23356, PIR: S17561, B40085 | - |
Drosophila melanogaster | - |
SwissProt: P35122, PIR: S33955 | - |
Homo sapiens | - |
UCH-L1, SwissProt: P09936, PIR: A25865, UCH-L3, SwissProt: P15374, PIR: A40085 | - |
Rattus norvegicus | - |
UCH-L1, SwissProt: Q00981 | - |
Oxidation Stability | Organism |
---|---|
active-site thiol is very sensitive to oxidation and requires reductants | Drosophila melanogaster |
active-site thiol is very sensitive to oxidation and requires reductants | Homo sapiens |
active-site thiol is very sensitive to oxidation and requires reductants | Rattus norvegicus |
active-site thiol is very sensitive to oxidation and requires reductants | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | accounts for about 2% of soluble protein in brain | Homo sapiens | - |
nurse cell | - |
Drosophila melanogaster | - |
ovary | - |
Drosophila melanogaster | - |
testis | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquitin-peptide + H2O | - |
Drosophila melanogaster | ? | - |
? | |
ubiquitin-peptide + H2O | - |
Homo sapiens | ? | - |
? | |
ubiquitin-peptide + H2O | - |
Rattus norvegicus | ? | - |
? | |
ubiquitin-peptide + H2O | - |
Bos taurus | ? | - |
? | |
ubiquitinyl-peptide + H2O | catalyses the hydrolysis of an ester or amide bond involving the C-terminal Gly76 of ubiquitin | Drosophila melanogaster | ubiquitin + peptide | - |
? | |
ubiquitinyl-peptide + H2O | catalyses the hydrolysis of an ester or amide bond involving the C-terminal Gly76 of ubiquitin | Homo sapiens | ubiquitin + peptide | - |
? | |
ubiquitinyl-peptide + H2O | catalyses the hydrolysis of an ester or amide bond involving the C-terminal Gly76 of ubiquitin | Rattus norvegicus | ubiquitin + peptide | - |
? | |
ubiquitinyl-peptide + H2O | catalyses the hydrolysis of an ester or amide bond involving the C-terminal Gly76 of ubiquitin | Bos taurus | ubiquitin + peptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | peptidase classification: clan CA, family C12, Merops ID: C12.001 | Drosophila melanogaster |
More | peptidase classification: clan CA, family C12, Merops ID: C12.001 | Homo sapiens |
More | peptidase classification: clan CA, family C12, Merops ID: C12.001 | Rattus norvegicus |
More | peptidase classification: clan CA, family C12, Merops ID: C12.001 | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Drosophila melanogaster |
7.5 | - |
- |
Homo sapiens |
7.5 | - |
- |
Rattus norvegicus |
7.5 | - |
- |
Bos taurus |