Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of Ctsz null mice and crossing with Ctsb-deficient mice harboring a transgene for the mammary duct-specific expression of polyoma middle T oncogene, PymT. The double mutant mice show significant and prominent delay of early and advanced tumor development, improved histopathologic tumor grading, as well as a 70% reduction in the number of lung metastases and an 80% reduction in the size of these metastases. The double deficiency of Ctsb and Ctsz exerts significant synergistic anticancer effects, whereas the single deficiencies demonstrate at least partial reciprocal compensation | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
cathepsin P | - |
Mus musculus |
cathepsin X | - |
Mus musculus |
cathepsin Z | - |
Mus musculus |
CTSZ | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice, overview | Mus musculus |