BRENDA - Enzyme Database
show all sequences of 3.4.18.1

Molecular cloning, tissue distribution and enzymatic characterization of cathepsin X from olive flounder (Paralichthys olivaceus)

Ahn, S.J.; Kim, N.Y.; Jeon, S.J.; Sung, J.H.; Je, J.E.; Seo, J.S.; Kim, M.S.; Kim, J.K.; Chung, J.K.; Lee, H.H.; Comp. Biochem. Physiol. B 151, 203-212 (2008)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
cDNA encoding for the proenzyme of PoCtX (proPoCtX) is expressed in Escherichia coli as a 57 kDa fusion protein with glutathione S-transferase
Paralichthys olivaceus
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
0.1 mM, proPoCtX: 51.3% inhibition, native PoCtX: 56.6% inhibition
Paralichthys olivaceus
antipain
0.1 mM, proPoCtX: 98.6% inhibition, native PoCtX: 97.6% inhibition
Paralichthys olivaceus
Aprotinin
0.1 mM, proPoCtX: 31.9% inhibition, native PoCtX: 51.3% inhibition
Paralichthys olivaceus
chymostatin
0.1 mM, proPoCtX: 35.4% inhibition, native PoCtX: 96.9% inhibition
Paralichthys olivaceus
E-64
0.1 mM, proPoCtX: 25.6% inhibition, native PoCtX: 98.6% inhibition
Paralichthys olivaceus
EDTA
0.1 mM, proPoCtX: 5.1% inhibition, native PoCtX: 14.2% inhibition
Paralichthys olivaceus
EGTA
0.1 mM, proPoCtX: 2.2% inhibition, native PoCtX: 25.6% inhibition
Paralichthys olivaceus
leupeptin
0.1 mM, proPoCtX: 99.1% inhibition, native PoCtX: 95.6% inhibition
Paralichthys olivaceus
additional information
recombinant proPoCtX is inhibited by antipain and leupeptin
Paralichthys olivaceus
NEM
0.1 mM, proPoCtX: 44.6% inhibition, native PoCtX: 67.0% inhibition
Paralichthys olivaceus
pepstatin A
0.1 mM, proPoCtX: 0% inhibition, native PoCtX: 36.0% inhibition
Paralichthys olivaceus
PMSF
0.1 mM, proPoCtX: 42.2% inhibition, native PoCtX: 37.2% inhibition
Paralichthys olivaceus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Paralichthys olivaceus
5829
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
33200
-
native PoCtX protein
Paralichthys olivaceus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Paralichthys olivaceus
Q58HF4
-
-
Purification (Commentary)
Commentary
Organism
purified 9.48fold via a one-step purification process using a DEAE-Sephagel HPLC column
Paralichthys olivaceus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
alimentary canal
-
Paralichthys olivaceus
-
brain
-
Paralichthys olivaceus
-
eye
-
Paralichthys olivaceus
-
gill
-
Paralichthys olivaceus
-
heart
-
Paralichthys olivaceus
-
intestine
-
Paralichthys olivaceus
-
kidney
-
Paralichthys olivaceus
-
liver
-
Paralichthys olivaceus
-
muscle
-
Paralichthys olivaceus
-
pyloric cecum
-
Paralichthys olivaceus
-
spleen
-
Paralichthys olivaceus
-
stomach
-
Paralichthys olivaceus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
364.5
-
cytosol extract
Paralichthys olivaceus
3457
-
DEAE-Sephagel, 9.48fold purification
Paralichthys olivaceus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
691910
Paralichthys olivaceus
?
-
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
691910
Paralichthys olivaceus
?
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Paralichthys olivaceus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5
-
recombinant proPoCtX
Paralichthys olivaceus
6
-
native PoCtX protein
Paralichthys olivaceus
Cloned(Commentary) (protein specific)
Commentary
Organism
cDNA encoding for the proenzyme of PoCtX (proPoCtX) is expressed in Escherichia coli as a 57 kDa fusion protein with glutathione S-transferase
Paralichthys olivaceus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
0.1 mM, proPoCtX: 51.3% inhibition, native PoCtX: 56.6% inhibition
Paralichthys olivaceus
antipain
0.1 mM, proPoCtX: 98.6% inhibition, native PoCtX: 97.6% inhibition
Paralichthys olivaceus
Aprotinin
0.1 mM, proPoCtX: 31.9% inhibition, native PoCtX: 51.3% inhibition
Paralichthys olivaceus
chymostatin
0.1 mM, proPoCtX: 35.4% inhibition, native PoCtX: 96.9% inhibition
Paralichthys olivaceus
E-64
0.1 mM, proPoCtX: 25.6% inhibition, native PoCtX: 98.6% inhibition
Paralichthys olivaceus
EDTA
0.1 mM, proPoCtX: 5.1% inhibition, native PoCtX: 14.2% inhibition
Paralichthys olivaceus
EGTA
0.1 mM, proPoCtX: 2.2% inhibition, native PoCtX: 25.6% inhibition
Paralichthys olivaceus
leupeptin
0.1 mM, proPoCtX: 99.1% inhibition, native PoCtX: 95.6% inhibition
Paralichthys olivaceus
additional information
recombinant proPoCtX is inhibited by antipain and leupeptin
Paralichthys olivaceus
NEM
0.1 mM, proPoCtX: 44.6% inhibition, native PoCtX: 67.0% inhibition
Paralichthys olivaceus
pepstatin A
0.1 mM, proPoCtX: 0% inhibition, native PoCtX: 36.0% inhibition
Paralichthys olivaceus
PMSF
0.1 mM, proPoCtX: 42.2% inhibition, native PoCtX: 37.2% inhibition
Paralichthys olivaceus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Paralichthys olivaceus
5829
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
33200
-
native PoCtX protein
Paralichthys olivaceus
Purification (Commentary) (protein specific)
Commentary
Organism
purified 9.48fold via a one-step purification process using a DEAE-Sephagel HPLC column
Paralichthys olivaceus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
alimentary canal
-
Paralichthys olivaceus
-
brain
-
Paralichthys olivaceus
-
eye
-
Paralichthys olivaceus
-
gill
-
Paralichthys olivaceus
-
heart
-
Paralichthys olivaceus
-
intestine
-
Paralichthys olivaceus
-
kidney
-
Paralichthys olivaceus
-
liver
-
Paralichthys olivaceus
-
muscle
-
Paralichthys olivaceus
-
pyloric cecum
-
Paralichthys olivaceus
-
spleen
-
Paralichthys olivaceus
-
stomach
-
Paralichthys olivaceus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
364.5
-
cytosol extract
Paralichthys olivaceus
3457
-
DEAE-Sephagel, 9.48fold purification
Paralichthys olivaceus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
691910
Paralichthys olivaceus
?
-
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
691910
Paralichthys olivaceus
?
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Paralichthys olivaceus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5
-
recombinant proPoCtX
Paralichthys olivaceus
6
-
native PoCtX protein
Paralichthys olivaceus
Other publictions for EC 3.4.18.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
732575
Pislar
Cathepsin X promotes 6-hydroxy ...
Rattus norvegicus
Neuropharmacology
82
121-131
2014
-
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1
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1
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1
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1
1
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731157
Bak
Molecular cloning, expression, ...
Patiria pectinifera
Appl. Biochem. Biotechnol.
169
847-861
2013
4
-
1
-
-
-
9
-
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1
-
-
5
-
1
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1
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5
1
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1
1
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4
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1
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9
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1
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1
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1
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5
1
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1
1
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731770
Chantree
Characterization and expressio ...
Fasciola gigantica
Exp. Parasitol.
132
249-256
2012
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1
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5
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1
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1
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2
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1
1
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732052
Bhutani
Cathepsins L and Z are critica ...
Mus musculus
J. Biol. Chem.
287
17471-17482
2012
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1
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1
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1
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1
1
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708633
Staudt
Cathepsin X is secreted by hum ...
Homo sapiens
Haematologica
95
1452-1460
2010
-
-
-
-
-
-
-
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2
-
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1
-
2
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9
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3
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2
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1
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9
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3
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-
-
-
-
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1
1
-
-
-
708738
Naegler
A cysteine-type carboxypeptida ...
Homo sapiens
Int. Immunopharmacol.
10
134-139
2010
-
1
1
-
-
-
-
-
-
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-
2
-
1
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1
1
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4
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1
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1
1
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2
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1
1
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4
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1
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1
1
-
2
2
710431
Sevenich
Synergistic antitumor effects ...
Mus musculus
Proc. Natl. Acad. Sci. USA
107
2497-2502
2010
-
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-
-
1
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1
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2
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2
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1
1
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693808
Krueger
Regulation of cathepsin X over ...
Homo sapiens
J. Pathol.
217
581-588
2009
1
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1
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3
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4
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4
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708023
Kos
The role of cathepsin X in cel ...
Homo sapiens
Cell Adh. Migr.
3
164-166
2009
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1
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1
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1
1
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708056
Obermajer
Cathepsin X-mediated beta2 int ...
Homo sapiens
Cell. Mol. Life Sci.
66
1126-1134
2009
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1
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3
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1
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1
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1
1
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708373
Obermajer
Cathepsin X prevents an effect ...
Homo sapiens
Eur. J. Cell Biol.
88
461-471
2009
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1
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2
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2
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2
1
1
2
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708379
Jevnikar
Cathepsin X cleaves the beta2 ...
Homo sapiens
Eur. J. Immunol.
39
3217-3227
2009
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1
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1
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1
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708748
Obermajer
Cathepsin X cleaves the C-term ...
Homo sapiens
Int. J. Biochem. Cell Biol.
41
1685-1696
2009
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1
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3
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1
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1
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2
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7
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1
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1
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7
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1
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683059
Cooke
Mapping of a novel susceptibil ...
Homo sapiens
Am. J. Respir. Crit. Care Med.
178
203-207
2008
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1
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683222
Bettegowda
Identification of novel bovine ...
Bos taurus
Biol. Reprod.
79
301-309
2008
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1
1
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1
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1
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1
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2
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683378
Kao
Cloning and expression of carp ...
Cyprinus carpio
Comp. Biochem. Physiol. B
149
541-551
2008
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1
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4
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1
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2
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1
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5
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683533
Obermajer
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Differential expression of cat ...
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Crystal structure of cathepsin ...
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Engineered human carboxypeptid ...
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Improved purification of cathe ...
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Histone hydrolase activity of ...
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Distelmaier
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